The inexpensive additive N-methylmorpholine effectively decreases the equivalents of nucleophiles in the catalytic highly enantioselective arylation of aryl aldehydes

被引：13

作者：

Wang, Pei ^{[1
]}

Liu, Yue ^{[1
]}

Zhang, Ya-Lun ^{[1
]}

Da, Chao-Shan ^{[1
,2
]}

机构：

[1] Lanzhou Univ, Inst Biochem & Mol Biol, Sch Life Sci, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, State Key Lab Organ Chem, Lanzhou, Peoples R China

来源：

CHIRALITY | 2017年 / 29卷 / 08期

基金：

中国国家自然科学基金;

关键词：

aryl aldehydes; arylation; asymmetric catalysis; NMM; triarylaluminum; ASYMMETRIC ARYLATION; GRIGNARD-REAGENTS; PHENYL TRANSFER; BORONIC ACIDS; ZINC EXCHANGE; IN-SITU; DERIVATIVES; ALCOHOLS; BROMIDES; DIARYLMETHANOLS;

D O I：

10.1002/chir.22709

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Highly enantioselective arylation of aryl aldehydes catalyzed by (S)-H-8-BINOL-Ti(Oi-Pr)(2) complex in the presence of N-methylmorpholine (NMM) as an effective and inexpensive additive is described for the first time. We found high enantioselectivity and yield but successfully reduced the equivalents of nucleophiles triarylaluminums by 50% compared with our previous report. The practicability of the process was thereby greatly increased.

引用

页码：443 / 450

页数：8