Synthesis of the Tetracyclic ABCD Ring Systems of Madangamines D-F

被引：18

作者：

Diaba, Faiza ^{[1
]}

Pujol-Grau, Climent ^{[1
]}

Martinez-Laporta, Agustin ^{[1
]}

Fernandez, Israel ^{[2
]}

Bonjoch, Josep ^{[1
]}

机构：

[1] Univ Barcelona, Fac Farm, IBUB, Lab Quim Organ, E-08028 Barcelona, Spain

[2] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Inorgan 1, E-28040 Madrid, Spain

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 03期

关键词：

1ST ENANTIOSELECTIVE SYNTHESIS; DIAZATRICYCLIC CORE; RADICAL CYCLIZATION; CLOSING METATHESIS; MARINE ALKALOIDS; CONCISE APPROACH; TRICYCLIC CORE; STEREOCHEMISTRY; ALKENES; ROUTE;

D O I：

10.1021/ol503586d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the tetracyclic cores of madangamines D-F was achieved, featuring a reductive radical process from an ethoxycarbonyldichloroacetamide to build the morphan nucleus, a Mitsunobu-type aminocyclization toward the common diazatricyclic intermediate, and ring-closing metathesis reactions for the macrocyclization step leading to the 13- to 15-membered rings.

引用

页码：568 / 571

页数：4

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