Quinolone-Induced Upregulation of Osteopontin Gene Promoter Activity in Human Lung Epithelial Cell Line A549

被引：4

作者：

Shiratori, Beata ^{[1
]}

Zhang, Jing ^{[2
]}

Usami, Osamu ^{[1
]}

Chagan-Yasutan, Haorile ^{[1
]}

Suzuki, Yasuhiko ^{[3
]}

Nakajima, Chie ^{[3
]}

Uede, Toshimitsu ^{[4
]}

Hattori, Toshio ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Div Emerging & Infect Dis, Sendai, Miyagi 980, Japan

[2] FUSO Pharmaceut Ind Ltd, Ctr Res & Dev, Osaka, Japan

[3] Hokkaido Univ, Res Ctr Zoonosis Control, Sapporo, Hokkaido, Japan

[4] Hokkaido Univ, Inst Genet Med, Div Mol Immunol, Sapporo, Hokkaido, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 06期

基金：

日本科学技术振兴机构;

关键词：

POSTTRANSLATIONAL MODIFICATIONS; HOST-RESISTANCE; CYTOKINE; EXPRESSION; MOXIFLOXACIN; ACTIVATION; FLUOROQUINOLONE; PHOSPHORYLATION; IDENTIFICATION; CIPROFLOXACIN;

D O I：

10.1128/AAC.06062-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Quinolones, in addition to their antibacterial activities, act as immunomodulators. Osteopontin (OPN), a member of the extracellular matrix proteins, was found to play a role in the immune and inflammatory response. We found that quinolones significantly enhanced OPN secretion, namely, garenoxacin (220%), moxifloxacin (62%), gatifloxacin (82%), sparfloxacin, (79%), and sitafloxacin (60%). Enhancement of OPN secretion was shown to be due to the effect of quinolones on the OPN gene promoter activity. We also examined the role of quinolones on apoptosis and found that sparfloxacin decreased the late apoptosis of A549 cells, but garenoxacin did not show the antiapoptotic effect. The antiapoptotic effects of quinolones do not appear to be associated with OPN elevation.

引用

页码：2868 / 2872

页数：5

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