Silencing PTEN, a negative regulator of the PI3K/AKT pathway, is not sufficient to confer protection against simulated ischaemia and reperfusion

被引:0
|
作者
Siddall, Hilary K. [1 ]
Davidson, Sean M. [1 ]
Mocanu, Mihaela M. [1 ]
Yellen, Derek M. [1 ]
机构
[1] UCL, Hatter Cardiovasc Inst, London WC1H 6HX, England
关键词
PTEN siRNA; caspase; 3; simulated ischaemia and reperfusion;
D O I
10.1016/j.yjmcc.2008.02.108
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
107
引用
收藏
页码:756 / 756
页数:1
相关论文
共 50 条
  • [1] PTEN/PI3K/Akt pathway is involved is involved in the protection of hydrogen sulfide against myocardium ischemic/reperfusion injury
    Kang, Tieduo
    Liu, Wenxian
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (12): : 16352 - 16359
  • [2] Cardioprotection from ischaemia-reperfusion injury: Dissecting the PI3K/AKT pathway with chemical inhibition of PTEN
    Siddall, Hilary K.
    Mocanu, Mihaela M.
    Yellon, Derek M.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 44 (04) : 755 - 756
  • [3] Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast
    Rodríguez-Escudero, I
    Roelants, FM
    Thorner, J
    Nombela, C
    Molina, M
    Cid, VJ
    BIOCHEMICAL JOURNAL, 2005, 390 : 613 - 623
  • [4] Role of the PI3K/AKT pathway and PTEN in otitis media
    Lee, Hwan Ho
    Chin, Anthony
    Pak, Kwang
    Wasserman, Stephen, I
    Kurabi, Arwa
    Ryan, Allen F.
    EXPERIMENTAL CELL RESEARCH, 2020, 387 (01)
  • [5] MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer
    Hu, Mingli
    Zhu, Shixuan
    Xiong, Shengwei
    Xue, Xingxing
    Zhou, Xiaodong
    ONCOLOGY REPORTS, 2019, 41 (03) : 1439 - 1454
  • [6] PTEN/PI3K/AKT PATHWAY DYSREGULATION IN MYELODYSPLASTIC GRANULOCYTES
    D'Alo, F.
    Fabiani, E.
    Giachelia, M.
    Fianchi, L.
    Falconi, G.
    Boncompagni, R.
    Criscuolo, M.
    Guidi, F.
    Voso, M. T.
    Leone, G.
    HAEMATOLOGICA, 2012, 97 : 135 - 135
  • [7] Modulation of telomere protection by the PI3K/AKT pathway
    Mendez-Pertuz, Marinela
    Martinez, Paula
    Blanco-Aparicio, Carmen
    Gomez-Casero, Elena
    Belen Garcia, Ana
    Martinez-Torrecuadrada, Jorge
    Palafox, Marta
    Cortes, Javier
    Serra, Violeta
    Pastor, Joaquin
    Blasco, Maria A.
    NATURE COMMUNICATIONS, 2017, 8
  • [8] Modulation of telomere protection by the PI3K/AKT pathway
    Marinela Méndez-Pertuz
    Paula Martínez
    Carmen Blanco-Aparicio
    Elena Gómez-Casero
    Ana Belen García
    Jorge Martínez-Torrecuadrada
    Marta Palafox
    Javier Cortés
    Violeta Serra
    Joaquin Pastor
    Maria A. Blasco
    Nature Communications, 8
  • [9] CARDIOPROTECTIVE EFFECT OF PI3K/AKT PATHWAY IN ISCHAEMIC POSTCONDITIONING AGAINST ISCHAEMIA AND REPERFUSION INDUCED INJURY IN ISOLATED RAT HEART
    Zhao Xin
    Quan NanHu
    HEART, 2010, 96 : A38 - A39
  • [10] A computational model for the PI3K/Akt/mTOR pathway predicts PTEN as a negative feedback loop
    Vanaja, Kiran
    Mukherjee, Radha
    Rosen, Neal
    Levchenko, Andre
    CANCER RESEARCH, 2020, 80 (16)