Vascular endothelial growth factor-C and its receptor VEGFR-3 in non-small-cell lung cancer: Concurrent expression in cancer cells from primary tumour and metastatic lymph node

被引:58
|
作者
Saintigny, Pierre
Kambouchner, Marianne
Ly, Madani
Gomes, Noelia
Sainte-Catherine, Odile
Vassy, Roger
Czernichow, Sebastien
Letoumelin, Philippe
Breau, Jean-Luc
Bernaudin, Jean-Francois
Kraemer, Michel
机构
[1] Hop Avicenne, Med Oncol Serv, AP HP, F-93009 Bobigny, France
[2] Univ Paris 13, Lab Oncol Cellulaire & Mol, EA 3410, Bobigny, France
[3] Hop Avicenne, Serv Anat & Cytol Pathol, AP HP, F-93009 Bobigny, France
[4] Univ Paris 06, Hop Tenon, Serv Histol Biol Tumorale, EA 3499, Paris, France
[5] Hop Avicenne, AP HP, Bobigny, France
[6] Hop Avicenne, Dept Interhosp Sante Publ, AP HP, Bobigny, France
关键词
vascular endothelial growth factor-C;
D O I
10.1016/j.lungcan.2007.06.021
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: Investigation of the role of vascular endothelial growth factor-C (VEGF-C) and VEGF receptor-3 (VEGFR-3) in non-small-cell lung cancer (NSCLC) has mainly focused on lymph node (LN) metastasis related to lymphangiogenesis. However, the coexpression of VEGF-C/VEGFR-3 by tumour cells can independently play an important role.
引用
收藏
页码:205 / 213
页数:9
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