In this study, laser cladding of Co-Cr-Mo alloy on a gamma-TiAl substrate was performed to investigate the wear behavior of coated and uncoated TiAl alloy at room temperature. Dry sliding wear tests were conducted for coated and uncoated counterfaces against three pins of alumina, Inconel 718 and Co-Cr-Mo. Overall, laser cladding of Co-Cr-Mo powder resulted in the formation of a thick coating with minimal imperfections, as well as increasing the wear resistance of TiAl alloy. The results of wear tests indicated that the relative wear resistance was about 1.97, 2.17, and 1.92 for sliding against alumina, Inconel 718, and Co-Cr-Mo pins, respectively. The investigation of worn surfaces also showed that the abrasive wear mechanism was dominant for all samples. In addition, severe abrasive wear was changed to mild abrasive wear by local formation of chromium-based oxides.