mRNA vaccine development for cholangiocarcinoma: a precise pipeline

被引：7
|
作者：
Tang, Tian-Yu [1 ,2 ,3 ,4 ,5 ]
Huang, Xing [1 ,2 ,3 ,4 ,5 ]
Zhang, Gang [1 ,2 ,3 ,4 ,5 ]
Lu, Ming-Hao [1 ,2 ,3 ,4 ,5 ]
Liang, Ting-Bo [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 1, Zhejiang Prov Key Lab Pancreat Dis, Sch Med, Hangzhou 310009, Peoples R China
[3] Zhejiang Clin Res Ctr Hepatobiliary & Pancreat Di, Hangzhou 310003, Zhejiang, Peoples R China
[4] Innovat Ctr Study Pancreat Dis Zhejiang Prov, Hangzhou 310009, Peoples R China
[5] Zhejiang Univ, Canc Ctr, Hangzhou 310058, Peoples R China
来源：
MILITARY MEDICAL RESEARCH | 2022年 / 9卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Cholangiocarcinoma (CHOL); mRNA vaccine; Tumor antigen; Immune subtype; Immune microenvironment; METASTATIC CHOLANGIOCARCINOMA; IMMUNE-RESPONSES; STRANDED-RNA; WEB SERVER; CANCER; CHEMOTHERAPY; RECOGNITION; MULTICENTER; GEMCITABINE; PEPTIDE;
D O I：
10.1186/s40779-022-00399-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cholangiocarcinoma (CHOL) is one of the most aggressive tumors worldwide and cannot be effectively treated by conventional and novel treatments, including immune checkpoint blockade therapy. The mRNA vaccine-based immunotherapeutic strategy has attracted much attention for various diseases, however, its application in CHOL is limited due to the thoughtlessness in the integration of vaccine design and patient selection. A recent study established an integrated path for identifying potent CHOL antigens for mRNA vaccine development and a precise stratification for identifying CHOL patients who can benefit from the mRNA vaccines. In spite of a promising prospect, further investigations should identify immunogenic antigens and onco-immunological characteristics of CHOL to guide the clinical application of CHOL mRNA vaccines in the future.
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页数：6
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