CAVEOLIN-1 AND BREAST CANCER: A New Clinical Perspective

被引：0
|
作者：
Mercier, Isabelle [1 ]
Lisanti, Michael P. [1 ]
机构：
[1] Thomas Jefferson Univ, Dept Stem Cell Biol & Regenerat Med, Philadelphia, PA 19107 USA
来源：
CAVEOLINS AND CAVEOLAE: ROLES IN SIGNALING AND DISEASE MECHANISMS | 2012年 / 729卷
关键词：
ONCOGENICALLY TRANSFORMED-CELLS; ANCHORAGE-INDEPENDENT GROWTH; STROMAL CAVEOLIN-1; DOWN-REGULATION; TUMOR-GROWTH; MAMMARY TUMORIGENESIS; SCAFFOLDING DOMAIN; GENE FAMILY; FIBROBLASTS; EXPRESSION;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The current chapter focuses on the role of Caveolin-1 (Cav-1) in cellular growth with an emphasis on its implication in breast cancer initiation, progression, clinical prognosis and as a potential therapeutic target. The role of Cav-1 as a tumor suppressor in breast cancer has emerged in the past few years, with dual functions on both cancer epithelium as well as the cancer stroma. Its multiple functions as a regulator of estrogen signaling and kinase activity and its newly found role as an important factor controlling the dynamic relationship between cancer epithelia and stroma position Cav-1 as a new therapeutic target for the treatment of breast cancer.
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页码：83 / 94
页数：12
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