Acidic triazoles as soluble guanylate cyclase stimulators

被引：22

作者：

Roberts, Lee R. ^{[1
]}

Bradley, Paul A. ^{[1
]}

Bunnage, Mark E. ^{[1
]}

England, Katherine S. ^{[1
]}

Fairman, David ^{[2
]}

Fobian, Yvette M. ^{[3
]}

Fox, David N. A. ^{[1
]}

Gymer, Geoff E. ^{[1
]}

Heasley, Steven E. ^{[3
]}

Molette, Jerome ^{[1
]}

Smith, Graham L. ^{[1
]}

Schmidt, Michelle A. ^{[3
]}

Tones, Michael A. ^{[4
]}

Dack, Kevin N. ^{[1
]}

机构：

[1] Pfizer, Worldwide Med Chem, Sandwich CT13 9NJ, Kent, England

[2] Pfizer, Pharmacokinet Dynam & Metab, Sandwich CT13 9NJ, Kent, England

[3] Pfizer, Worldwide Med Chem, Chesterfield, MI USA

[4] Pfizer, Indicat Discovery, St Louis, MO 63108 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 21期

关键词：

Soluble guanylate cyclase; Enzyme; Stimulator; Triazoles;

D O I：

10.1016/j.bmcl.2011.08.071

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF(3) triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6515 / 6518

页数：4

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