Reactions to learning a "not elevated" amyloid PET result in a preclinical Alzheimer's disease trial

BackgroundThe experiences of biomarker-ineligible cognitively normal persons can inform trial conduct and the translation of preclinical Alzheimer's disease (AD) into clinical practice.MethodsWe interviewed 33 persons whose not elevated brain amyloid imaging biomarker result made them ineligible for a preclinical AD trial.ResultsMost participants (n=17) reported being informed that they did not demonstrate adequately elevated amyloid to qualify, whereas some (n=14) reported being told they had no amyloid or plaques. Relief (n=17) and disappointment related to not being able to participate (n=12) were the most common reactions to results. Nearly all participants would have made healthy lifestyle changes if they had received an elevated result, would have another scan, and would participate in another AD prevention trial.ConclusionsAlthough some participants may misconstrue results, disclosure of a not elevated amyloid result in the research setting causes little behavior change; willingness to participate in AD research remains.