The INK4a/ARF network in tumour suppression

被引：767
|
作者：
Sherr, CJ [1 ]
机构：
[1] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Dept Tumor Cell Biol, Memphis, TN 38105 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 10期
关键词：
D O I：
10.1038/35096061
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.
引用
收藏
页码：731 / 737
页数：7
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