Penehyclidine hydrochloride attenuates cerebral vasospasm after subarachnoid hemorrhage

被引：0
|
作者：
Tang, Yan [1 ]
Chen, Xiaoyi [2 ]
Liu, Jin [1 ]
机构：
[1] Sichuan Univ, W China Hosp, Lab Anesthesiol & Crit Care Med, Chengdu 610041, Sichuan Provinc, Peoples R China
[2] Sichuan Univ, W China Med Sch, Dept Clin Med, Chengdu 610041, Sichuan Provinc, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 22期
关键词：
subarachnoid hemorrhage; vasospasm; intracranial; penehyclidine hydrochloride; brain injury; PREVENTS VASOSPASM; INJURY;
D O I：
10.3969/j.issn.1673-5374.2011.22.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A new cholinergic antagonist, penehyclidine hydrochloride (PHC), was developed independently by Chinese scientists. Administration of PHC into muscle and the cisterna magna could relieve basilar artery vasospasm following subarachnoid hemorrhage in animals. In addition, injecting PHC into the cisterna magna had better therapeutic effect. Moreover, PHC had the capability of reducing the expression of neuron specific enolase and S-100 beta protein in cerebrospinal fluid. There was no effect on the number of surviving neurons in the hippocampal CA1 region, or on the levels of superoxide dismutase and malondialdehyde.
引用
收藏
页码：1725 / 1730
页数：6
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