Revealing some oncofetal antigens in peripheral blood mononuclear cells of donors and patients with B-chronic lymphocytic leukemia

被引：1
|
作者：
Penezina, O
Komissarenko, S
Tishenco, L
Pavlenco, A
Moroz, S
Bulgakov, A
Fomovskaia, G [1 ]
机构：
[1] Natl Acad Sci Ukraine, AV Palladin Biochem Inst, Kiev, Ukraine
[2] Ukrainian Minist Hlth, Inst Doctors Postgrad Educ, Kiev, Ukraine
[3] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far E Dept, Vladivostok 690022, Russia
来源：
LEUKEMIA RESEARCH | 1998年 / 22卷 / 11期
关键词：
leukemia; leukocytes; carcinoembryonic antigen; trophoblast specific glycoprotein; embryonic prealbumin;
D O I：
10.1016/S0145-2126(98)00123-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Eidelman et al. showed that the expression of functional carcinoembryonic antigen (CEA) on the surface of cells can block terminal differentiation and maintain their proliferative capabilities. This led us to analyze the expression of CEA, trophoblast-specific beta-1-glycoprotein (TSG) and embryonic prealbumin-l (EPA) in peripheral blood mononuclear cells (PBMs) isolated from healthy donors and patients with B-chronic lymphocytic leukemia (B-CLL). We demonstrated that the PBMs of patients with B-CLL differed from PBMs of healthy donors by having greater numbers of CEA-, EPA- and TSG-positive cells. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
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页码：1009 / 1013
页数：5
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