DAP-2, the Drosophila homolog of transcription factor AP-2

被引：28
|
作者：
Monge, I [1 ]
Mitchell, PJ [1 ]
机构：
[1] Univ Zurich, Inst Pharmacol, CH-8057 Zurich, Switzerland
来源：
MECHANISMS OF DEVELOPMENT | 1998年 / 76卷 / 1-2期
关键词：
transcription factor AP-2; DAP-2; DNA binding domain; Drosophila embryogenesis; procephalic neuroectoderm; maxillary segment; protocerebrum; ventral nerve cord; antennomaxillary complex; imaginal disk; antenna; optic lobe; sense organ development;
D O I：
10.1016/S0925-4773(98)00125-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Transcription factor AP-2 is essential for craniofacial. nervous system, and limb development in the mouse. We report here the cloning and expression pattern analysis of DAP-2, the Drosophila homolog of AP-2 family genes. DAP-2 is expressed in discrete regions of procephalic neuroectoderm, the brain, ventral nerve cord, and maxillary segment during Drosophila embryogenesis, and in the brain, optic lobes, ventral nerve cord, antenno-maxillary complex, and antennal and leg imaginal disks in third instar larvae. Protein sequence conservation and parallels between the embryonic expression patterns of DAP-2 and mammalian AP-2 family genes indicate that transcription factor AP-2 has been structurally and functionally conserved during metazoan evolution. (C) 1998 Elsevier Science Ireland Ltd. All lights reserved.
引用
收藏
页码：191 / 195
页数：5
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