Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ9-tetrahydrocannabinol (THC)

被引:27
|
作者
Olarte-Sanchez, C. M. [1 ]
Valencia-Torres, L. [1 ]
Cassaday, H. J. [2 ]
Bradshaw, C. M. [1 ]
Szabadi, E. [1 ]
机构
[1] Univ Nottingham, Psychopharmacol Sect, Div Psychiat, Nottingham NG7 2UH, England
[2] Univ Nottingham, Sch Psychol, Nottingham NG7 2UH, England
基金
英国医学研究理事会;
关键词
Progressive-ratio schedule; Mathematical Principles of Reinforcement; Mathematical model; Food deprivation; Sucrose; Corn oil; Delta(9)-Tetrahydrocannabinol; Incentive value; Rat; VARIABLE-INTERVAL SCHEDULES; QUALITATIVELY DIFFERENT REINFORCERS; ACID-INDUCED LESIONS; MATHEMATICAL PRINCIPLES; CANNABINOID RECEPTOR; RESPONSE RATE; MATCHING THEORY; CB1; RECEPTORS; BODY-WEIGHT; STEP-SIZE;
D O I
10.1016/j.beproc.2015.01.014
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Rats' performance on a progressive-ratio schedule maintained by sucrose (0.6 M, 50 mu l) and corn oil (100%, 25 mu l) reinforcers was assessed using a model derived from Killeen's (1994) theory of schedule-controlled behaviour, 'Mathematical Principles of Reinforcement'. When the rats were maintained at 80% of their free-feeding body weights, the parameter expressing incentive value, a, was greater for the corn oil than for the sucrose reinforcer; the response-time parameter, delta, did not differ between the reinforcer types, but a parameter derived from the linear waiting principle (T-o), indicated that the minimum post-reinforcement pause was longer for corn oil than for sucrose. When the rats were maintained under free-feeding conditions, a was reduced, indicating a reduction of incentive value, but delta was unaltered. Under the food-deprived condition, the CBI cannabinoid receptor agonist Delta(9)-tetrahydrocannabinol (THC: 0.3, 1 and 3 mg kg(-1)) increased the value of a for sucrose but not for corn oil, suggesting a selective enhancement of the incentive value of sucrose; none of the other parameters was affected by THC. The results provide new information about the sensitivity of the model's parameters to deprivation and reinforcer quality, and suggest that THC selectively enhances the incentive value of sucrose. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:122 / 131
页数:10
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