Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

被引：1
|
作者：
Tissing, Wim J. E. [1 ]
Lauten, Melchior [2 ]
Meijerink, Jules P. P. [1 ]
den Boer, Monique L. [1 ]
Koper, Jan Willem [3 ]
Sonneveld, Peter [4 ]
Pieters, Rob [1 ]
机构：
[1] Erasmus MC, Erasmus MC Sophia Childrens Hosp, Dept Pediat Oncol Hematol, Dr Molewaterpl 60, NL-3015 GJ Rotterdam, Netherlands
[2] Hannover Med Sch, Dept Pediat Hematol & Oncol, Hannover, Germany
[3] Erasmus MC, Dept Endocrinol, Rotterdam, Netherlands
[4] Erasmus MC, Dept Haematol, Rotterdam, Netherlands
来源：
HAEMATOLOGICA | 2005年 / 90卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the gluco-corticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.
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页码：1279 / +
页数：3
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