Outcomes in women with history of gestational diabetes mellitus Screening and prevention of type 2 diabetes mellitus Literature review

Women with a history of gestational diabetes mellitus (GDM) are characterized by a high risk of type 2 diabetes mellitus (T2DM) (X 7), metabolic syndrome (X 2 to 5) and cardiovascular diseases (X 1,7) Women with lesser degrees of glucose intolerance share the same risks T2DM may occur from postpartum (5 to 14%) to several years later, up to 25 years Some factors associated with T2DM are identified obesity, early diagnostic before 24 weeks, high pregnancy OGTT blood glucose or insulinotherapy Screening for T2DM only with fasting glucose provides less sensibility than with OGTT, HbA1c may supplant these dosages The recurrence rate of GDM is between 30 and 84%, non white ethnicity and insulinotherapy during GDM being the best proven predictors High risk women need repeated life long screenings for glycemic abnomalies, or when another pregnancy is planned Among overweight or obese women with history of GDM who show minor glycoregulation disturbances, it is proved that modifications of lifestyle in intensive programs or metformin halve the risk of DT2 However, studies analysing practices show low adhesion to screening, without an intensive program, few women implement lifestyle modifications These intensive programs should be implemented and proposed to high risk women Their therapeutic education should also include prevention of cardiovascular risk factors (C) 2010 Elsevier Masson SAS All rights reserved