KRASG12D, pulmonary LCH, and atorvastatin

被引：1
|
作者：
Aouba, Achille [1 ]
机构：
[1] Univ Caen Normandy, Caen, France
来源：
BLOOD | 2017年 / 130卷 / 04期
关键词：
LANGERHANS CELL HISTIOCYTOSIS; MUTATIONS;
D O I：
10.1182/blood-2017-06-788455
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Kamata et al(1) elegantly demonstrate in mice that (1) KRAS(G12D) (but not BRAF(V600E)) mutation transfection in pulmonary myeloid cells induces an isolated pulmonary (IP)-Langerhans cell histiocytosis (LCH)-like neoplasm, via phosphatidylinositol 3-kinase (PI3K) activation, and that (2) atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A inhibitor that inhibits RAS interaction of PI3K, reduces tumor burden in vivo.
引用
收藏
页码：391 / 392
页数：4
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