S-1 plus cisplatin with concurrent radiotherapy for locally advanced thymic carcinoma: Study protocol of LOGIK1605/JART-1501

被引：5

作者：

Fukuda, Minoru ^{[1
]}

Funaki, Soichiro ^{[2
]}

Yamazaki, Takuya ^{[3
]}

Sato, Shuntaro ^{[4
]}

Mukae, Hiroshi ^{[5
]}

Takenoyama, Mitsuhiro ^{[6
]}

Fukuoka, Junya ^{[7
]}

Nabeshima, Kazuki ^{[8
]}

Tateyama, Hisashi ^{[9
]}

Ashizawa, Kazuto ^{[10
]}

Hara, Masaki ^{[11
]}

Seto, Takashi ^{[6
]}

Okumura, Meinoshin ^{[12
,13
]}

Sugio, Kenji ^{[14
,15
]}

机构：

[1] Nagasaki Univ Hosp, Clin Oncol Ctr, 1-7-1 Sakamoto, Nagasaki 8528501, Japan

[2] Osaka Univ, Grad Sch Med, Dept Gen Thorac Surg, Osaka, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Radiol, Nagasaki, Japan

[4] Nagasaki Univ Hosp, Clin Res Ctr, Nagasaki, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Dept Resp Med, Nagasaki, Japan

[6] Natl Hosp Org Kyusyu Canc Ctr, Dept Thorac Oncol, Fukuoka, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan

[8] Fukuoka Univ, Dept Pathol, Fac Med, Fukuoka, Japan

[9] Kasugai Municipal Hosp, Dept Pathol, Kasugai, Aichi, Japan

[10] Nagasaki Univ, Grad Sch Biomed Sci, Dept Clin Oncol, Nagasaki, Japan

[11] Nagoya City West Med Ctr, Dept Radiol, Nagoya, Aichi, Japan

[12] Osaka Toneyama Med Ctr, Osaka, Japan

[13] JART, Osaka, Japan

[14] Oita Univ, Fac Med, Dept Thorac & Breast Surg, Oita, Japan

[15] LOGiK, Fukuoka, Japan

来源：

THORACIC CANCER | 2020年 / 11卷 / 03期

关键词：

Cisplatin; radiotherapy; S-1; thymic carcinoma; PHASE-II; CHEMOTHERAPY; CANCER;

D O I：

10.1111/1759-7714.13319

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thymic carcinoma is a rare epithelial tumor of the thymus with a poor prognosis, and multimodal approaches are important for its treatment. Recently, a number of studies have indicated that S-1 treatment is effective against thymic carcinoma. S-1 plus cisplatin with concurrent radiotherapy is a commonly used treatment for other malignancies, including non-small cell lung cancer (NSCLC). In addition, its safety has been confirmed, and it has been reported to have a marked effect against thymic carcinoma. Therefore, we conducted a phase II study of S-1 plus cisplatin with concurrent thoracic radiotherapy for locally advanced thymic carcinoma, in which the overall response rate was employed as the primary endpoint. The secondary endpoints were overall survival, progression-free survival, and safety.

引用

页码：693 / 696

页数：4

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