Stereocontrolled synthesis of alpha,alpha-disubstituted alpha-aminoaldehydes and alpha-aminoacids using a [3,3] allylic trichloracetimidate rearrangement

被引：20

作者：

Imogai, H ^{[1
]}

Petit, Y ^{[1
]}

Larcheveque, M ^{[1
]}

机构：

[1] ECOLE NORMALE SUPER,CNRS,ORGAN SYNTH LAB,F-75231 PARIS 05,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 15期

关键词：

D O I：

10.1016/0040-4039(96)00393-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sigmatropic rearrangement of trichloracetimidates derived from syn monoprotected allylic diols 3 resulting from the condensation of vinylalanes or cuprates with alpha-alkoxyaldehydes afforded diastereomerically pure allylic amines 6. The oxidative cleavage of these amines allowed the access to alpha,alpha-disubstituted alpha-aminoacids in high enantiomeric purity. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：2573 / 2576

页数：4

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