Urethane-induced lung carcinogenesis

被引：16
|
作者：
Sozio, Francesca [1 ,2 ]
Schioppa, Tiziana [1 ,2 ]
Sozzani, Silvano [3 ]
Del Prete, Annalisa [1 ,2 ]
机构：
[1] Univ Brescia, Dept Mol & Translat Med, Brescia, Italy
[2] IRCCS, Humanitas Clin & Res Ctr, Milan, Italy
[3] Sapienza Univ Rome, Dept Mol Med, Lab Ist Pasteur Italia Fdn Cenci Bolognetti, Rome, Italy
来源：
CARCINOGEN-DRIVEN MOUSE MODELS OF ONCOGENESIS | 2021年 / 163卷
关键词：
ETHYL CARBAMATE; SUSCEPTIBILITY; TUMORS; MICE;
D O I：
10.1016/bs.mcb.2020.09.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chemical induced carcinogenesis together with genetically engineered mouse models represent important approaches for the study of the complex mechanisms involving genotype and environmental factors in cancer development, including lung cancer. The induction of lung tumor in mice with urethane (ethyl carbamate) is considered a valuable model of Kras-driven lung cancer. However, inbred mouse strains show variable susceptibility to lung tumor formation, with C57BL/6 background, widely used to study many transgenic and null mutations, highly resistant to lung carcinogenesis. Here is described a protocol of urethane-induced lung cancer effective in lung tumor induction in C57BL/6J strain. Multiple urethane injections are needed to overcome genetic resistance and induce in a reproducible manner lung carcinogenesis in C57BL/6J background mice.
引用
收藏
页码：45 / 57
页数：13
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