Comparative Analysis of Biological Networks Hidden Markov model and Markov chain-based approach

The diverse cellular mechanisms that sustain the life of living organisms are carried out by numerous biomolecules, such as deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs), and proteins. Over the past few decades, significant research efforts have been made to sequence the genomes of various species and to search these genomes to track down genes that give rise to proteins and noncoding RNAs (ncRNAs) [1], [2]. As a result, the catalog of known functional molecules in cells has experienced a rapid expansion. ©2012 IEEE.