Activities of flucytosine, fluconazole, amphotericin B, and-micafungin in a murine model of disseminated infection by Candida glabrata

被引：14
|
作者：
Mariné, M [1 ]
Serena, C [1 ]
Fernández-Torres, B [1 ]
Pastor, FJ [1 ]
Guarro, J [1 ]
机构：
[1] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Microbiol, E-43201 Reus, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 11期
关键词：
D O I：
10.1128/AAC.49.11.4757-4759.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.
引用
收藏
页码：4757 / 4759
页数：3
相关论文
共 50 条
  • [1] COMPARISON OF FLUCONAZOLE, AMPHOTERICIN-B AND FLUCYTOSINE IN TREATMENT OF A MURINE MODEL OF DISSEMINATED INFECTION WITH CANDIDA-GLABRATA IN IMMUNOCOMPROMISED MICE
    ATKINSON, BA
    BOUTHET, C
    BOCANEGRA, R
    CORREA, A
    LUTHER, MF
    GRAYBILL, JR
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 35 (05) : 631 - 640
  • [2] Efficacy of a new formulation of amphotericin B in a murine model of disseminated infection by Candida glabrata
    Marine, Marcal
    Espada, Raquel
    Torrado, Juan
    Pastor, F. Javier
    Guarro, Josep
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (04) : 880 - 883
  • [3] Treatment of Candida glabrata using topical amphotericin B and flucytosine
    Shann, S
    Wilson, J
    SEXUALLY TRANSMITTED INFECTIONS, 2003, 79 (03) : 265 - 266
  • [4] Efficacy of a new formulation of amphotericin B in murine disseminated infections by Candida glabrata or Candida tropicalis
    Marine, Marcal
    Espada, Raquel
    Torrado, Juan
    Javier Pastor, F.
    Guarro, Josep
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2009, 34 (06) : 566 - 569
  • [5] In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species
    Nishi, Isao
    Sunada, Atsuko
    Toyokawa, Masahiro
    Asari, Seishi
    Iwatani, Yoshinori
    JOURNAL OF INFECTION AND CHEMOTHERAPY, 2009, 15 (01) : 1 - 5
  • [6] Antifungal Activities of Diphenyl Diselenide alone and in Combination with Fluconazole or Amphotericin B against Candida glabrata
    Denardi, Laura Bedin
    Nunes Mario, Debora Alves
    de Loreto, Erico Silva
    Nogueira, Cristina Wayne
    Santurio, Janio Morais
    Alves, Sydney Hartz
    MYCOPATHOLOGIA, 2013, 176 (1-2) : 165 - 169
  • [7] Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections
    White, DJ
    Habib, AR
    Vanthuyne, A
    Langford, S
    Symonds, M
    SEXUALLY TRANSMITTED INFECTIONS, 2001, 77 (03) : 212 - 213
  • [8] Treatment of Candida glabrata infection in immunosuppressed mice by using a combination of liposomal amphotericin B with caspofungin or micafungin
    Olson, JA
    Adler-Moore, JP
    Smith, PJ
    Proffitt, RT
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) : 4895 - 4902
  • [9] Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalis
    Warn, PA
    Sharp, A
    Morrissey, G
    Denning, DW
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (03) : 590 - 593
  • [10] Efficacy of amphotericin B and fluconazole in the murine mycotic (Candida albicans) mastitis model
    Guhad, FA
    Jensen, HE
    Hau, J
    SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE, 1999, 26 (01) : 24 - 30
12345