Radon-induced proteomic profile of lung tissue in rats

被引：15
|
作者：
Xu, Nai-Yu [2 ]
Zhang, Su-Ping [1 ,3 ]
Nie, Ji-Hua [1 ,3 ]
Li, Jian-Xiang [1 ,3 ]
Tong, Jian [1 ,3 ]
机构：
[1] Soochow Univ, Sch Radiat Med & Publ Hlth, Dept Toxicol, Suzhou, Peoples R China
[2] Soochow Univ, Coll Pharm, Suzhou, Peoples R China
[3] Key Lab Radiat Med & Protect Jiangsu Province, Suzhou, Peoples R China
来源：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2008年 / 71卷 / 06期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1080/15287390701798669
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The aim of this study was to investigate the differential expression of proteins in lung of rats following long-term exposure to radon. The total proteins of lung tissue from Wistar rats exposed to radon for cumulative doses up to 100, 200, or 400 WLM (working level months) were isolated by two-dimensional electrophoresis (2-DE) and analyzed with ImageMaster 2D Platinum software. Comparison of the 2-DE images between the control and radon-exposed groups resulted in 14 upregulated and 9 downregulated protein spots, of which 15 were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) or matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/TOF-MS). The simultaneous up-expressions of RAGE and S100A6 indicated that both proteins might be applied as biomarkers for lung injury induced by long-term radon exposure.
引用
收藏
页码：361 / 366
页数：6
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