Eliminating Hormones With Orally Active Gonadotropin-releasing Hormone Antagonists

被引：3
|
作者：
Kotlyar, Alexander M. [1 ]
Pal, Lubna [1 ]
Taylor, Hugh S. [1 ]
机构：
[1] Yale Univ, Yale Sch Med, Dept Obstet Gynecol & Reprod Sci, Sect Reprod Endocrinol & Infertil, New Haven, CT 06520 USA
来源：
CLINICAL OBSTETRICS AND GYNECOLOGY | 2021年 / 64卷 / 04期
关键词：
GnRH antagonist; GnRH analogue; pituitary suppression; elagolix; linzagolix; relugolix; ENDOMETRIOSIS-ASSOCIATED PAIN; SHORT-TERM TREATMENT; LUTEINIZING-HORMONE; GNRH-ANTAGONIST; LEUPROLIDE ACETATE; POTENT ANTAGONIST; UTERINE FIBROIDS; STEM-CELLS; AGONISTS; ELAGOLIX;
D O I：
10.1097/GRF.0000000000000664
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Gonadotropin-releasing hormone (GnRH) analogues have been used in clinical practice for nearly 3 decades. Beginning with GnRH agonists, these agents have been used to treat hormone-dependent disease and to suppress gonadotropin production in assisted reproductive technologies. With the development of GnRH antagonists and especially small-molecule antagonists, our ability to achieve gonadotropin and sex steroid suppression has become increasingly effective and convenient. In this review, we will briefly describe the development of GnRH analogues, review the evolution of orally active small-molecule GnRH antagonists and provide an overview of the expanding role of small-molecule GnRH antagonists in clinical practice.
引用
收藏
页码：837 / 849
页数：13
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