Host and Microbiome Genome-Wide Association Studies: Current State and Challenges

被引：67

作者：

Awany, Denis ^{[1
]}

Allali, Imane ^{[2
]}

Dalvie, Shareefa ^{[3
]}

Hemmings, Sian ^{[4
]}

Mwaikono, Kilaza S. ^{[2
]}

Thomford, Nicholas E. ^{[1
]}

Gomez, Andres ^{[5
]}

Mulder, Nicola ^{[2
]}

Chimusa, Emile R. ^{[1
]}

机构：

[1] Univ Cape Town, Inst Infect Dis & Mol Med, Div Human Genet, Dept Pathol,Fac Hlth Sci, Cape Town, South Africa

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Computat Biol Div, Dept Integrat Biomed Sci,Fac Hlth Sci, Cape Town, South Africa

[3] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa

[4] Stellenbosch Univ, Dept Psychiat, Fac Med & Hlth Sci, Cape Town, South Africa

[5] Univ Minnesota Twin Cities, Dept Anim Sci, St Paul, MN USA

来源：

FRONTIERS IN GENETICS | 2019年 / 9卷

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

genome-wide association study; microbiome; microbiome-GWAS; host-genetic; host-microbiome interaction; OF-FUNCTION VARIANTS; HUMAN GUT MICROBIOME; GENETIC-VARIATION; BETA DIVERSITY; FRAMEWORK; SELECTION; PATHWAYS; IMMUNITY; LINKING; AGE;

D O I：

10.3389/fgene.2018.00637

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The involvement of the microbiome in health and disease is well established. Microbiome genome-wide association studies (mGWAS) are used to elucidate the interaction of host genetic variation with the microbiome. The emergence of this relatively new field has been facilitated by the advent of next generation sequencing technologies that enable the investigation of the complex interaction between host genetics and microbial communities. In this paper, we review recent studies investigating host-microbiome interactions using mGWAS. Additionally, we highlight the marked disparity in the sampling population of mGWAS carried out to date and draw attention to the critical need for inclusion of diverse populations.

引用

页数：12

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