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Modeling cortisol rhythms in a population-based study

被引：60
|
作者：
Ranjit, N
Young, EA
Raghunathan, TE
Kaplan, GA
机构：
[1] Univ Michigan, Sch Publ Hlth, Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, Ann Arbor, MI 48104 USA
[2] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Survey Res Ctr, Ann Arbor, MI 48109 USA
来源：
PSYCHONEUROENDOCRINOLOGY | 2005年 / 30卷 / 07期
关键词：
cortisol; diurnal profile; regression splines; mixed models;
D O I：
10.1016/j.psyneuen.2005.02.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of these analyses was to develop and describe easily implementable, yet information rich, approaches for analysis of the temporal profile of cortisol in human populations. A typical waking profile of cortisol in a sample of women aged 15-44 was parameterized by a piecewise Linear regression model, implemented as a mixed model to accommodate repeated observations among individuals. The model was extended to distinguish characteristic cortisol profiles of obese women from those of non-obese women. Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：615 / 624
页数：10
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