Synthesis of 1,4-oxathiocines and thiopyrans by the reaction of 2-amino-4,5-dihydro-3-thiophenecarbonitriles with ethyl diazoacetoacetate

被引：0
|
作者：
Yamagata, K
Akizuki, K
Yamazaki, M
机构：
来源：
LIEBIGS ANNALEN | 1996年 / 05期
关键词：
thiophenes; 1,4-oxathiocines; 2H-thiopyrans;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of 4,5-dihydro-2-(4-morpholinyl)- or -2-(1-piperidinyl)- or -2-(1-pyrrolidinyl)-3-thiophenecarbonitriles 1a-i with ethyl diazoacetoacetate in the presence of rhodium(II) acetate dimer gave the corresponding ethyl 1,4-oxathiocine-3-carboxylates 2a-f, h and acetyl(dihydro-1-thiophenylio)-(ethoxycarbonyl)methanides 3a, b. Compounds 2a-f, h and 3a, b were heated at. 140 degrees C to give the corresponding ethyl thiopyran-6-carboxylates 4a-i in moderate to good yields.
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收藏
页码：725 / 729
页数：5
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