Human T-Cell leukemia virus type 1 Tax and cellular transformation

被引：29
|
作者：
Peloponese, Jean-Marie, Jr. [1 ]
Kinjo, Takao [1 ]
Jeang, Kuan-Teh [1 ]
机构：
[1] NIAID, Natl Inst Hlth, Mol Microbiol Lab, Mol Virol Sect, Bethesda, MD USA
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2007年 / 86卷 / 02期
关键词：
human T-cell leukemia virus 1 (HTLV-1); adult T-cell leukemia (ATL); Tax; NF-kappa B; transformation;
D O I：
10.1532/IJH97.07087
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Infection of T-cells by human T-cell leukemia virus type 1 (HTLV-1) causes a lymphoproliferative malignancy known as adult T-cell leukemia (ATL). ATL is characterized by abnormal lymphocytes, called flower cells, which have cleaved and convoluted nuclei. Tax, encoded by the HTLV-1 pX region, is a critical nonstructural protein that plays a central role in leukemogenesis; however, the mechanisms of HTLV-1 oncogenesis have not been clarified fully. In this review, we summarize current thinking on how Tax may affect ATL leukemogenesis.
引用
收藏
页码：101 / 106
页数：6
相关论文
共 50 条
  • [1] Human T-Cell Leukemia Virus Type 1 Tax and Cellular Transformation
    Jean-Marie Peloponese
    Takao Kinjo
    Kuan-Teh Jeang
    [J]. International Journal of Hematology, 2007, 86 : 101 - 106
  • [2] Cellular transformation by human T-cell leukemia virus type I
    Ressler, S
    Connor, LM
    Marriott, SJ
    [J]. FEMS MICROBIOLOGY LETTERS, 1996, 140 (2-3) : 99 - 109
  • [3] The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes
    Ross, TM
    Pettiford, SM
    Green, PL
    [J]. JOURNAL OF VIROLOGY, 1996, 70 (08) : 5194 - 5202
  • [4] Centrosome amplification in adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells
    Nitta, Takayuki
    Kanai, Masayuki
    Sugihara, Eiji
    Tanaka, Masakazu
    Sun, Binlian
    Nagasawa, Toshiro
    Sonoda, Shunro
    Saya, Hideyuki
    Miwa, Masanao
    [J]. CANCER SCIENCE, 2006, 97 (09) : 836 - 841
  • [5] Roles of miRNAs in virus-mediated cellular transformation: lessons from human T-cell leukemia virus type 1
    Yeung, Man Lung
    Jeang, Kuan-Teh
    [J]. FUTURE VIROLOGY, 2011, 6 (11) : 1351 - 1360
  • [6] Transformation studies with a human T-cell leukemia virus type 1 molecular clone
    Anderson, MD
    Ye, JX
    Xie, L
    Green, PL
    [J]. JOURNAL OF VIROLOGICAL METHODS, 2004, 116 (02) : 195 - 202
  • [7] Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia
    Chan, Chi-Ping
    Kok, Kin-Hang
    Jin, Dong-Yan
    [J]. INFECTIOUS AGENTS ASSOCIATED CANCERS: EPIDEMIOLOGY AND MOLECULAR BIOLOGY, 2017, 1018 : 147 - 166
  • [8] Ubiquitination of human T-Cell leukemia virus type 1 tax modulates its activity
    Peloponese, JM
    Iha, H
    Yedavalli, VRK
    Miyazato, A
    Li, Y
    Haller, K
    Benkirane, M
    Jeang, KT
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (21) : 11686 - 11695
  • [9] Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
    Cherian, Mathew A.
    Baydoun, Hicham H.
    Al-Saleem, Jacob
    Shkriabai, Nikoloz
    Kvaratskhelia, Mamuka
    Green, Patrick
    Ratner, Lee
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (43) : 26270 - 26281
  • [10] Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Ishioka, Kojiro
    Higuchi, Masaya
    Takahashi, Masahiko
    Yoshida, Sakiko
    Oie, Masayasu
    Tanaka, Yuetsu
    Takahashi, Sugata
    Xie, Li
    Green, Patrick L.
    Fujii, Masahiro
    [J]. RETROVIROLOGY, 2006, 3 (1)
12345