The productivity of plants is greatly affected by various environmental stresses. Soil salinity affects plant growth and development by way of osmotic stress, injurious effects of toxic Na+ and Cl- ions and to some extent Cl- and SO42- of Mg2+ and nutrient imbalance caused by excess of Na+ and Cl- ions. Salinity stress response is multigenic, as a number of processes involved in the tolerance mechanism are affected, such as various compatible solutes/osmolytes, polyamines, reactive oxygen species and antidoxidant defence mechanism, ion transport and compartmentalization of injurious ions. Various genes/cDNAs encoding proteins involved in the above-mentioned processes have been identified and isolated. The role of genes/cDNAs encoding proteins involved in regulating other genes/proteins, signal transduction process involving hormones like ABA, JA and polyamines, and strategies to improve salinity stress tolerance have also been discussed.