Successful pregnancy in a patient suffering from recurrent mid-trimester miscarriage with C9 deficiency after receiving cervical cerclage followed by clindamycin and progesterone: A case report

被引：4

作者：

Watanabe, Noriyoshi ^{[1
]}

Suzuki, Tomo

Kitano, Etsuko ^{[2
]}

Kitamura, Hajime ^{[3
]}

Hatanaka, Michiyo ^{[2
]}

Sago, Haruhiko

机构：

[1] Natl Ctr Child Hlth & Dev, Dept Maternal Fetal & Neonatal Med, Setagaya Ku, Tokyo 1578535, Japan

[2] Kobe Tokiwa Univ, Fac Hlth Sci, Dept Med Technol, Kobe, Hyogo, Japan

[3] Kansai Univ Welf Sci, Fac Hlth Sci Welf, Dept Nutr Sci Well Being, Suita, Osaka, Japan

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2012年 / 38卷 / 03期

关键词：

complement component 9; mid-trimester; miscarriage; pregnancy; PRETERM BIRTH; COMPLEMENT; COMPONENT; PREVENTION; WOMEN;

D O I：

10.1111/j.1447-0756.2011.01731.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Complement component 9 (C9) deficiency is relatively common, especially in Japan. Here we present the case of a 27-year-old Japanese woman whose obstetric history involved three mid-trimester miscarriages (at 22 weeks', 18 weeks' and 21 weeks' gestation) and one early spontaneous miscarriage. Her fifth pregnancy was successfully managed by cervical cerclage at 13 weeks' gestation, followed by clindamycin administration (600 mg/day for 7 days) and progesterone injections (250 mg/week). She gave birth to a healthy 3326-g male infant at 40 weeks and 1 day gestation after natural onset of labor. After delivery, the serum complement components were analyzed. C9 protein and activity were undetectable in the patient's serum. We suggest that an immunologic disorder such as C9 deficiency should be considered as a potential complication of undiagnosed recurrent miscarriages.

引用

页码：562 / 566

页数：5