Genetic polymorphisms of ERCC-1 and ERCC-2 are not prognostic markers in osteosarcoma patients with chemotherapy A meta-analysis in Chinese population

Aim: To make an accurate estimation of the association of ERCC1 and ERCC2 polymorphisms with osteosarcoma (OS) prognosis in Chinese population. Methods: Total 7 qualified studies with 1404 osteosarcoma patients were included. Odds ratios (OR) with 95% CIs were pooled for the survival rate in different osteosarcoma patients with ERCC1 and ERCC2 genetic polymorphisms. The heterogeneity was assessed by I-2 test. Potential publication bias was assessed by Begg funnel plot and Egger linear regression test. Results: In rs11615, no significant association was found under dominant [TT+TC vs. CC: OR=1.252, 95% CI: 0.864-1.815, P=.235], recessive [TT vs. TC+CC: OR=0.850, 95% CI: 0.695-1.030, P=.095] or allelic model [T vs. C Allele: OR=1.219, 95% CI: 0.922-1.612, P=.165]. In rs13181, no significant association was found under dominant [AA+AC vs. CC: OR=1.031, 95% CI: 0.800-1.329, P=.801], recessive [AA vs. AC+CC: OR=1.005, 95% CI: 0.875, 1.154, P=.944] or allelic model [A vs. C Allele: OR=1.009, 95% CI: 0.903-1.128, P=.870]. In rs1799793, no significant association was found under dominant [GG+GA vs. AA: OR=1.134, 95% CI: 0.884-1.454, P=.322, recessive [GG vs. AG+AA: OR=1.025, 95% CI: 0.881-1.192, P=.750], or allelic model [G vs. A Allele: OR=1.046, 95% CI: 0.930-1.177, P=.450]. Conclusion: This study did not support rs11615, rs13181 or rs1799793 to be used as surrogate markers for clinical outcome of osteosarcoma with chemotherapy.