The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes

被引：54

作者：

Drago, Antonio ^{[1
]}

Crisafulli, Concetta ^{[2
]}

Sidoti, Antonina ^{[2
]}

Serretti, Alessandro ^{[1
]}

机构：

[1] Univ Bologna, Inst Psychiat, I-40123 Bologna, Italy

[2] Polyclin Univ Messina, Dept Biomorphol & Biotechol, Div Biol & Genet, Messina, Italy

来源：

PROGRESS IN NEUROBIOLOGY | 2011年 / 94卷 / 04期

关键词：

Major depression; Monoaminergic; Glutamate; Candidate gene; Variation; METHYL-D-ASPARTATE; LONG-TERM POTENTIATION; MEDIAL PREFRONTAL CORTEX; MGLU2/3 RECEPTOR AGONIST; PROTEIN-KINASE-II; C-FOS EXPRESSION; EXCITATORY SYNAPTIC-TRANSMISSION; POSITIVE ALLOSTERIC MODULATOR; CYCLIC ADENOSINE-MONOPHOSPHATE; ANXIETY-RELATED BEHAVIOR;

D O I：

10.1016/j.pneurobio.2011.05.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：418 / 460

页数：43

共 5 条

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