The polycyclic aromatic hydrocarbons (PAHs)-induced toxicity in asphalt workers neutrophils through induction of oxidative stress

Objective Asphalt is known as an important source of exposure to polycyclic aromatic hydrocarbons (PAHs). PAHs are one of the major concerns of the workplace and the scientific community, and have high stability and various toxicity effects. Methods Since asphalt workers are exposed to PAHs, this study was designed to evaluate the exposure of asphalt workers to PAHs and oxidative stress in neutrophils isolated from the workers. Results Results showed that exposure of asphalt workers with different PAHs is lower than the standard set. The level of reactive oxygen species (ROS), lipid peroxidation (LPO), and glutathione disulfide (GSSG) in neutrophils isolated from the blood of asphalt workers were significantly higher than the normal group. Glutathione (GSH) levels and GSH/GSSG ratio in neutrophils isolated from the blood of asphalt workers were significantly lower than in the normal group. Conclusion Results suggest that due to the lower level of exposure to PAHs compared to the standard level, the level of oxidative stress in these workers is high. Based on the toxic effects and the lack of a standard level for some PAHs, the use of personal protective equipment and the use of antioxidants is recommended.