Prevalence and possible causes of hypouricemia at a tertiary care hospital

被引:18
|
作者
Son, Chang-Nam [1 ]
Kim, Ji-Min [1 ]
Kim, Sang-Hyon [1 ]
Cho, Soo-Kyung [2 ]
Choi, Chan-Bum [2 ]
Sung, Yoon-Kyoung [2 ]
Kim, Tae-Hwan [2 ]
Bae, Sang-Cheol [2 ]
Yoo, Dae-Hyun [2 ]
Jun, Jae-Bum [2 ]
机构
[1] Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Daegu, South Korea
[2] Hanyang Univ, Coll Med, Hosp Rheumat Dis, Dept Rheumatol, 222-1 Wangsimni Ro, Seoul 04763, South Korea
来源
KOREAN JOURNAL OF INTERNAL MEDICINE | 2016年 / 31卷 / 05期
关键词
Hypouricemia; Uric acid; IDIOPATHIC RENAL HYPOURICEMIA; URIC-ACID; CLINICAL-SIGNIFICANCE; URATE EXCRETION; POPULATION; SLC22A12; JAPANESE; SLC2A9; GENE; OUTPATIENTS;
D O I
10.3904/kjim.2015.125
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: We aimed to investigate the prevalence and possible causes of hypouricemia in the Korean population and to compare our findings with published results of other populations. Methods: We examined the serum uric acid levels of 30,757 subjects who had their uric acid values measured at least once during a 1-year period. All individuals with hypouricemia (serum uric acid < 2.0 mg/dL, n = 424) were reviewed with respect to medical drug history and concomitant diseases previously identified as being associated with hypouricemia. Results: The prevalence of hypouricemia was 4.14% (299/7,223) among inpatients and 0.53% (125/23,534) among outpatients, for an overall prevalence of 1.39% (424/30,757). Possible causes associated with hypouricemia were found to be solid or hematologic malignancies (n = 86), diabetes mellitus (n = 56), and therapeutic drugs (n = 29). The medications were allopurinol (n = 11), angiotensin II receptor blockers (n = 10), salicylates (n = 6), febuxostat (n = 1), and warfarin (n = 1). In the remaining 226 individuals, the cause of hypouricemia was not identified. Conclusions: Hypouricemia is relatively common in the Korean population compared to those of other countries. The possible causes associated with hypouricemia are related to underlying diseases and medications.
引用
收藏
页码:971 / 976
页数:6
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