Comparison of Drug Resistance Scores for Tipranavir in Protease Inhibitor-Naive Patients Infected with HIV-1 B and Non-B Subtypes

被引：6

作者：

Stuermer, Martin ^{[1
]}

Stephan, Christoph ^{[2
]}

Gute, Peter ^{[3
]}

Knecht, Gaby ^{[3
]}

Bickel, Markus ^{[2
]}

Brodt, Hans-Reinhard ^{[2
]}

Doerr, Hans W. ^{[1
]}

Guertler, Lutz ^{[1
]}

Lecocq, Pierre ^{[4
]}

van Houtte, Margriet ^{[4
]}

机构：

[1] JW Goethe Univ Hosp, Inst Med Virol, D-60596 Frankfurt, Germany

[2] JW Goethe Univ Hosp, HIVCENTER, D-60596 Frankfurt, Germany

[3] Infektiologikum, Frankfurt, Germany

[4] Virco BVBA, Turnhout, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 11期

关键词：

HIV-1-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; SUSCEPTIBILITY; SENSITIVITY; PREVALENCE; VARIANTS; IDENTIFICATION; INDIVIDUALS; COMBINATION; PROTEINASE;

D O I：

10.1128/AAC.00611-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genotypes of samples from protease inhibitor-naive patients in Frankfurt's HIV Cohort were analyzed with five tipranavir resistance prediction algorithms. Mean scores were higher in non-B than in B subtypes. The proportion of non-B subtypes increased with increasing scores, except in weighted algorithms. Virtual and in vitro phenotype analyses of samples with increased scores showed no reduced tipranavir susceptibility. Current algorithms appear suboptimal for interpretation of resistance to tipranavir in non-B subtypes; increased scores might reflect algorithm bias rather than "natural resistance."

引用

页码：5362 / 5366

页数：5

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