GC3 of Genes Can Be Used as a Proxy for Isochore Base Composition: A Reply to Elhaik et al.

被引：14

作者：

Clay, Oliver K. ^{[1
,2
,3
]}

Bernardi, Giorgio ^{[3
]}

机构：

[1] Univ Rosario, Sch Med & Hlth Sci, Bogota, Colombia

[2] Corp Invest Biol, Cellular & Mol Biol Unit, Medellin, Colombia

[3] Lab Mol Evolut, Stn Zool A Dohrn, Naples, Italy

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 2011年 / 28卷 / 01期

关键词：

isochores; GC3; GC level; genome composition; long-range correlations; chromatin; TRANSPOSABLE ELEMENTS; FISH GENOMES; HETEROGENEITY; CHROMOSOMES; MOUSE;

D O I：

10.1093/molbev/msq222

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In an article published in these pages, Elhaik et al. (Elhaik E, Landan G, Graur D. 2009. Can GC content at third-codon positions be used as a proxy for isochore composition? Mol Biol Evol. 26:1829-1833) asked if GC3, the GC level of the third-codon positions in protein-coding genes, can be used as a "proxy" to estimate the GC level of the surrounding isochore. We use available data to directly answer this simple question in the affirmative and show how the use of indirect methods can lead to apparently conflicting conclusions. The answer reasserts that in human and other vertebrates, genes have a strong tendency to reside in compositionally corresponding isochores, which has far-reaching implications for genome structure and evolution.

引用

页码：21 / 23

页数：3

共 7 条

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