Influence of molecular weight fractionation on the antimicrobial and anticancer properties of a fucoidan rich-extract from the macroalgae Fucus vesiculosus

被引：25

作者：

Cabral, Eduarda M. ^{[1
]}

Mondala, Julie Rose Mae ^{[2
]}

Oliveira, Marcia ^{[3
]}

Przyborska, Joanna ^{[4
]}

Fitzpatrick, Stephen ^{[5
]}

Rai, Dilip K. ^{[1
]}

Sivagnanam, Saravana Periaswamy ^{[1
]}

Garcia-Vaquero, Marco ^{[6
]}

O'Shea, Denis ^{[2
]}

Devereux, Michael ^{[2
]}

Tiwari, Brijesh K. ^{[1
]}

Curtin, James ^{[2
]}

机构：

[1] Teagasc Food Res Ctr Ashtown, Dublin 15, Ireland

[2] Technol Univ Dublin, Coll Sci & Hlth, Sch Food Sci & Environm Hlth, City Campus, Dublin, Ireland

[3] Univ Leon, Inst Food Sci & Technol, Dept Food Hyg & Technol, Leon, Spain

[4] Munster Technol Univ, Shannon Appl Biotechnol Ctr, Tralee, Kerry, Ireland

[5] Nutramara Ltd, Beechgrove House,Strand St, Tralee, Ireland

[6] Univ Coll Dublin, Sch Agr & Food Sci, Dublin, Ireland

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 186卷

基金：

欧盟地平线“2020”; 爱尔兰科学基金会;

关键词：

Fucoidan; Laminarin; Weight fractionation; Brown macroalgae; Antimicrobial properties; Anticancer properties; FUCOPHLORETHOL; LAMINARIN; SEAWEED; AGENT;

D O I：

10.1016/j.ijbiomac.2021.06.182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The objective of this study was to investigate the antimicrobial and anticancer properties of a fucoidan extract and subsequent fractions isolated from the macroalgae Fucus vesiculosus. The fractions obtained ( 10 kDa) could inhibit the growth of B. subtilis, E. coli, L. innocua and P. fluorescens when assayed at concentrations between 12,500 and 25,000 ppm. The bacterial growth was monitored by optical density (OD) measurements (600 nm, 24 h) at 30 degrees C or 37 degrees C, depending upon on the strain used. The extracted fractions were also tested for cytotoxicity against brain glioblastoma cancer cells using the Alamar Blue assay for 24 h, 48 h and 6 days. The 300 kDa fraction presented the lowest IC50 values (0.052% 24 h; 0.032% - 6 days). The potential bioactivity of fucoidan as an antimicrobial and anticancer agent was demonstrated in this study. Hence, the related mechanisms of action should be explored in a near future.

引用

页码：994 / 1002

页数：9

共 2 条

[1] Antibacterial properties of a glycolipid-rich extract and active principle from Nunavik collections of the macroalgae Fucus evanescens C. Agardh (Fucaceae)
Amiguet, Virginie Treyvaud
Jewell, Linda E.
Mao, Halimasadia
Sharma, Manju
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Durst, Tony
Allard, Marc
Rochefort, Guy
Arnason, John Thor
[J]. CANADIAN JOURNAL OF MICROBIOLOGY, 2011, 57 (09) : 745 - 749
[2] Fucoidan extract from brown seaweed (Sargassum echinocarpum): molecular weight, elemental composition, selectivity and anticancer activity against breast cancer cells
Yunianta, Yunianta
Laeliocattleya, Rosalina Ariesta
Wulan, Siti Narsito
Risjani, Yenny
[J]. NATURAL PRODUCT RESEARCH, 2024,

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