Synthesis of cationic glucosamino nucleic acids for stabilizing oligonucleotides

被引：4

作者：

Kitamura, Yoshiaki ^{[1
,2
]}

Moribe, Shuichi ^{[1
]}

Kitade, Yukio ^{[1
,2
,3
]}

机构：

[1] Gifu Univ, Dept Biomol Sci, Grad Sch Engn, 1-1 Yanagido, Gifu 5011193, Japan

[2] Gifu Univ, Fac Engn, Dept Chem & Biomol Sci, 1-1 Yanagido, Gifu 5011193, Japan

[3] Aichi Inst Technol, Fac Engn, Dept Appl Chem, 1247 Yachigusa,Yakusa Cho, Toyota, Aichi 4700392, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 19期

基金：

日本学术振兴会;

关键词：

Glucosamine; Nucleic acids; Oligonucleotides; Pyranosyl nucleosides; Zwitterionic nucleotides; HEXITOL; ANALOGS; HNA;

D O I：

10.1016/j.bmcl.2018.08.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glucosamino nucleic acids (GANAs) bearing a beta-N-glycoside bond between carbon 1 of the glucosamine and the nucleobase nitrogen were synthesized and incorporated into oligonucleotides (4',6'-GANA and 3',6'-GANA). The thermal stability of oligonucleotide duplexes containing the GANA zwitterionic nucleotides was also investigated.

引用

页码：3174 / 3176

页数：3

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