The effects of testosterone on transgender males on carotid intima-media thickness and serum inflammatory markers compared within patients with polycystic ovary syndrome

被引:5
|
作者
Balik, Ayse Ozlem [1 ]
Vural, Fisun [2 ]
Alpogan, Oksan [3 ]
Ozogul, Murat [1 ]
Donmez, Emin Erhan [2 ]
机构
[1] Univ Hlth Sci, Haydarpasa Numune Training & Res Hosp, Dept Radiol, Tibbiye St 23, TR-34668 Istanbul, Turkey
[2] Haydarpa Numune Training & Res Hosp, Univ Hlth Sci, Dept Obstet & Gynecol, Istanbul, Turkey
[3] Univ Hlth Sci, Haydarpasa Numune Training & Res Hosp, Dept Ophtalmol, Istanbul, Turkey
关键词
Hyperandrogenism; transgender persons; polycystic ovary syndrome; carotid intima-media thickness; body mass index; BLOOD-CELL COUNT; LYMPHOCYTE RATIO; RISK PROFILE; YOUNG-WOMEN; NEUTROPHIL; PCOS; SEX;
D O I
10.1080/09513590.2022.2112942
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate the effects of testosterone on carotid intima-media thickness (CIMT) and serum inflammatory markers compared within transgender males (TGM-Former called female-to-male) and polycystic ovary syndrome (PCOS). Methods: The prospective observational study included 30 TGM, 30 patients with PCOS, and 30 healthy women. Groups were compared for CIMT and hematologic inflammatory markers white blood cell (WBC), lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV). Results: The CIMT of the TGM group was 0.48 +/- 0.09 mm was significantly higher than PCOS (0.41 +/- 0.09 mm, p = .005) and the control group (0.38 +/- 0.7 mm, p = .001). The mean NLR, LMR, and MPV values were similar (p > .05). TGM had higher WBC levels compared to control women (p = .029). TGM had significantly lower PLR compared to PCOS and the control group (p = .001). CIMT were related to age (r = .390, p = .04) and body mass index (BMI) (r = .392, p = .03) in TGM. Conclusion: Increased CIMT in TGM individuals is not associated with inflammation; it seems to be a deleterious effect of exogenous testosterone exposure. Since increased CIMT may be a sign of serious cardiovascular problems developing in the future, it is suggested that it will be beneficial for these individuals should undergo clinical and radiological evaluation at regular intervals.
引用
收藏
页码:771 / 775
页数:5
相关论文
共 50 条
  • [1] Increased common carotid intima-media thickness in obese patients with polycystic ovary syndrome
    Barcellos, Cristiano Roberto
    Miguel Marcondes, Jose Antonio
    ATHEROSCLEROSIS SUPPLEMENTS, 2007, 8 (03) : 3 - 3
  • [2] Association of kallistatin with carotid intima-media thickness in women with polycystic ovary syndrome
    Calan, Mehmet
    Guler, Asli
    Unal Kocabas, Gokcen
    Alarslan, Pinar
    Bicer, Merve
    Imamoglu, Cetin
    Yuksel, Arif
    Bozkaya, Giray
    Bilgir, Oktay
    MINERVA ENDOCRINOLOGICA, 2018, 43 (03) : 236 - 245
  • [3] Does Carotid Intima-media Thickness have Relationship with Polycystic Ovary Syndrome?
    Allameh, Zahra
    Rouholamin, Safoura
    Adibi, Atusa
    Mehdipour, Mehrnaz
    Adeli, Maryam
    INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 2013, 4 (11) : 1266 - 1270
  • [4] Carotid intima-media thickness in women with polycystic ovary syndrome and matched controls
    Kim, J. J.
    Choi, Y. M.
    Kang, J. H.
    Hwang, K. R.
    Chae, S. J.
    Kim, S. M.
    Yoon, S. H.
    Ku, S. Y.
    Kim, S. H.
    Kim, J. G.
    Moon, S. Y.
    HUMAN REPRODUCTION, 2013, 28 : 331 - 332
  • [5] Asymmetric dimethylorginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome
    Verit, Fatma Ferda
    Vural, Mehmet
    FERTILITY AND STERILITY, 2009, 92 (01) : E12 - E12
  • [6] Evaluation of Carotid Artery Intima-Media Thickness as a Cardiovascular Risk Factor in Patients With Polycystic Ovary Syndrome
    Bahat, Pinar Yalcin
    Ozel, Alper
    Demirci, Alper
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2021, 13 (01)
  • [7] Asymmetric dimethylorginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome Reply
    Pamuk, Baris Onder
    FERTILITY AND STERILITY, 2009, 92 (01) : E13 - E13
  • [8] Carotid intima-media thickness in polycystic ovary syndrome and its association with hormone and lipid profiles
    Jabbour, Rhea
    Ott, Johannes
    Eppel, Wolfgang
    Frigo, Peter
    PLOS ONE, 2020, 15 (04):
  • [9] Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea
    Minoguchi, K
    Yokoe, T
    Tazaki, T
    Minoguchi, H
    Tanaka, A
    Oda, N
    Okada, S
    Ohta, S
    Naito, H
    Adachi, M
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 172 (05) : 625 - 630
  • [10] Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis
    Meyer, Michelle L.
    Malek, Angela M.
    Wild, Robert A.
    Korytkowski, Mary T.
    Talbott, Evelyn O.
    HUMAN REPRODUCTION UPDATE, 2012, 18 (02) : 112 - 126