Transient neonatal myasthenia gravis following maternal myasthenia gravis presenting in pregnancy after treatment with Alemtuzumab

被引：0
|
作者：
Dhugga, Lauren [1 ]
Geethanath, Ruppa [1 ]
Onwuneme, Chike [1 ]
机构：
[1] South Tyneside & Sunderland NHS Fdn Trust, Sunderland Royal Hosp, Neonatal Intens Care Unit, Kayll Rd, Sunderland SR4 7TP, England
来源：
CASE REPORTS IN PERINATAL MEDICINE | 2020年 / 9卷 / 01期
关键词：
alemtuzumab; Myasthenia gravis; neonatal;
D O I：
10.1515/crpm-2020-0065
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Ojectives: Transient neonatal Myasthenia gravis is a postsynaptic neuromuscular junction disorder seen in 10-21% of infants born to mothers with myasthenia gravis. Alemtuzumab is an anti-CD52 monoclonal antibody used in the treatment of multiple sclerosis. The possibility of developing Myasthenia gravis in a pregnant mother treated with Alemtuzumab is rare. Case presentation: We report a case of transient neonatal myasthenia gravis following treatment with Alemtuzumab for multiple sclerosis in the mother. Conclusions: Therapy with Alemtuzumab increases the risk of secondary autoimmune diseases including Myasthenia gravis.
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