Synthesis of peptides employing Fmoc-amino acid chlorides and commercial zinc dust

被引：36
|
作者：
Gopi, HN [1 ]
Babu, VS [1 ]
机构：
[1] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 52期
关键词：
D O I：
10.1016/S0040-4039(98)02169-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Coupling of Fmoc-amino acid chlorides mediated by activated commercial zinc dust for the synthesis of peptides is described. The reaction is carried out in an organic medium. The necessity of using an inorganic base like NaHCO3/Na2CO3 or an organic base like DIEA/NMM/TEA/pyridine is circumvented. The coupling is reasonably fast, clean, racemization free and high yielding. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9769 / 9772
页数：4
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