Preparation of 2-Magnesiated 1,3,5-Triazines via an Iodine-Magnesium Exchange

被引：21
|
作者：
Peng, Zhihua [1 ]
Haag, Benjamin A. [1 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 23期
基金：
欧洲研究理事会;
关键词：
HIGHLY SELECTIVE SYNTHESIS; ACIDIC HYDROGEN-ATOMS; CENTER-DOT-LICL; FUNCTIONALIZED ARYLMAGNESIUM; GRIGNARD COMPOUNDS; COUPLING REACTIONS; CROSS-COUPLINGS; DIRECTED ORTHO; ZINC REAGENTS; DERIVATIVES;
D O I：
10.1021/ol102173z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Functionalized iodo- and diiodo-1,3,5-triazine derivatives readily undergo an I/Mg exchange with BuMgCl, sBuMgCl, or OctMgBr at low temperatures. furnishing 2-magnesiated and 2-zincated 1,3,5-triazines (after transmetalation with ZnCl2). This method also offers a convenient access to dimagnesiated triazines. Furthermore, it allows the preparation of functionalized 1,3,5-triazinyl dimers and trimers, interesting for their optoelectronic properties.
引用
收藏
页码：5398 / 5401
页数：4
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