Developing a nontypeable Haemophilus influenzae (NTHi) vaccine

被引：93
|
作者：
Poolman, JT
Bakaletz, L
Cripps, A
Denoel, PA
Forsgren, A
Kyd, J
Lobet, Y
机构：
[1] SmithKline Beecham Biol, B-1330 Rixensart, Belgium
[2] Ohio State Univ, Coll Med & Publ Hlth, Childrens Res Inst, Div Mol Med,Dept Pediat, Columbus, OH 43205 USA
[3] Univ Canberra, Div Sci & Design, Canberra, ACT 2601, Australia
[4] Univ Lund, Malmo Univ Hosp, Dept Med Biol, S-20502 Malmo, Sweden
来源：
VACCINE | 2000年 / 19卷
关键词：
NTHi (or nontypable Haemophilus influenzae); animal models; otitis; LPD; LB1/fimbrin/P5; OMP26; vaccine research;
D O I：
10.1016/S0264-410X(00)00288-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is a current high demand for nontypable Haemophilus influenzae (NTHi) vaccines. Various options for the composition of such vaccines are possible. Decisions about the vaccine composition have to take into account the antigenic variability of NTHi, so even complex immunogens such as whole bacteria would preferentially have a tailor-made antigenic composition. We will present a summary of NTHi vaccine development, describing research efforts from SmithKline Beecham and other laboratories. Currently, major (P1, P2, P4, P5) and minor (P6, D15, TbpA/B,...) outer membrane proteins, LPS, adhesins (HMW, Hia, pili, P5) are being studied. Preclinical results with LPD, P5 (LB1) and OMP26 from our laboratories will be described including the use of animal models of otitis and lung infection. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：S108 / S115
页数：8
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