Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling

被引：151

作者：

Yang, Y. C. ^{[1
,2
]}

Zhang, N. ^{[1
]}

Van Crombruggen, K. ^{[1
]}

Hu, G. H. ^{[2
]}

Hong, S. L. ^{[2
]}

Bachert, C. ^{[1
]}

机构：

[1] Univ Ghent, Upper Airway Res Lab, Dept Oto Rhino Laryngol, B-9000 Ghent, Belgium

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Oto Rhino Laryngol, Chongqing, Peoples R China

来源：

ALLERGY | 2012年 / 67卷 / 10期

关键词：

airway disease; inflammation; remodeling; transforming growth factor-beta; REGULATORY T-CELLS; OBSTRUCTIVE PULMONARY-DISEASE; POLYP-DERIVED FIBROBLASTS; PARANASAL SINUS DISEASE; TGF-BETA ACTIVATION; QUALITY-OF-LIFE; CHRONIC RHINOSINUSITIS; MYOFIBROBLAST DIFFERENTIATION; STAPHYLOCOCCUS-AUREUS; COLLAGEN PRODUCTION;

D O I：

10.1111/j.1398-9995.2012.02880.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Airway diseases such as chronic rhinosinusitis, asthma, and chronic obstructive pulmonary disorder are characterized by inflammation and remodeling. Among inflammatory and extracellular matrix regulatory cytokines, transforming growth factor-beta (TGF-beta) stands central, as it possesses both important immunomodulatory and fibrogenic activities, and should be considered a key for understanding inflammation and remodeling processes. This review will briefly summarize the recent findings on the role of TGF-beta 1, from the view points of inflammation and remodeling, and discuss the role of TGF-beta in the upper and lower airway diseases. This may reveal new perspectives in the understanding of airway inflammation and remodeling processes and may open innovative treatment strategies for the regulation of TGF-beta 1.

引用

页码：1193 / 1202

页数：10

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