An efficient and expeditious synthesis of 1,2,4-triazolidine-3-thiones using meglumine as a reusable catalyst in water

被引：5

作者：

Masram, Liklesha B. ^{[1
]}

Salim, Simren S. ^{[1
]}

Barkule, Angad B. ^{[1
]}

Gadkari, Yatin U. ^{[2
]}

Telvekar, Vikas N. ^{[1
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Mumbai, Maharashtra, India

[2] Inst Chem Technol, Mumbai Marathwada Campus, Jalna 431213, Maharashtra, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2022年 / 134卷 / 03期

关键词：

Meglumine; Green Chemistry; Cyclocondensation; One-pot synthesis; ONE-POT SYNTHESIS; CONCENTRATED SOLAR-RADIATION; SOLVENT-FREE SYNTHESIS; MULTICOMPONENT STRATEGY; PREPARATIVE-SCALE; IONIC LIQUID; GREEN; DERIVATIVES; FACILE; 5-ARYL-1,2,4-TRIAZOLIDINE-3-THIONES;

D O I：

10.1007/s12039-022-02087-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, convenient, and eco-friendly procedure has been developed using meglumine (15 mol%) as a green catalyst for the synthesis of 1,2,4-triazolidine-3-thiones under one-pot condition. Variously substituted aldehydes or ketones reacted well with thiosemicarbazide to give desired compounds in extremely good quantity. The developed protocol offers several advantages such as shorter reaction times, mild reaction conditions, easy workup, simple purification procedures, water as a solvent, and wide substrate scope tolerance. Further, the catalyst was recycled (up to 4 cycles) without compromising the yield of the final products.

引用

页数：7

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