RETRACTED: Effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis (Retracted Article)

被引：0

作者：

Lin Xiuqing ^{[1
]}

Huang Zhiming ^{[1
]}

Wu Fang ^{[1
]}

Huang Erjiong ^{[1
]}

Chen Xin ^{[1
]}

Jin Ruifang ^{[1
]}

Chen Renping ^{[1
]}

Wu Wei ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou, Zhejiang, Peoples R China

来源：

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | 2018年 / 17卷 / 10期

关键词：

Bifidobacteria; MIMBb75; Ulcerative colitis; Intestinal injury; Intestinal flora;

D O I：

10.4314/tjpr.v17i10.18

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Purpose: To investigate the effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis (UC). Methods: Mouse model of UC was produced using dextran sulphate sodium (DSS). The mice were divided into seven groups, viz, reference group, MRS-L medium-negative control group, mesalamine-positive control group, high dose bifidobacteria (MIMBb75) group, middle dose MIMBb75 group and low dose MIMBb75 group. Normal mice were used as control. All mice were sacrificed at day 7 of treatment, and colon length, hemoglobin concentration and intestinal flora were determined. Results: Bifidobacteria inhibited UC-induced decreases in mice hemoglobin and UC-induced colon shortening. In addition, it augmented the diversity of intestinal flora and increased the number of bacteroides and Clostridium leptum. Conclusion: Bifidobacteria plays a therapeutic role in UC via regulation of intestinal micro flora.

引用

页码：2019 / 2023

页数：5

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