Pseudomonas aeruginosa tssC1 Links Type VI Secretion and Biofilm-Specific Antibiotic Resistance

被引:72
|
作者
Zhang, Li [1 ]
Hinz, Aaron J. [1 ]
Nadeau, Jean-Paul [1 ]
Mah, Thien-Fah [1 ]
机构
[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
ESCHERICHIA-COLI; SYSTEM; PROTEIN; MOTILITY; LOCUS;
D O I
10.1128/JB.00268-11
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Biofilm-specific antibiotic resistance is influenced by multiple factors. We demonstrated that Pseudomonas aeruginosa tssC1, a gene implicated in type VI secretion (T6S), is important for resistance of biofilms to a subset of antibiotics. We showed that tssC1 expression is induced in biofilms and confirmed that tssC1 is required for T6S.
引用
收藏
页码:5510 / 5513
页数:4
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