Ellagic Acid and Its Anti-Aging Effects on Central Nervous System

被引:30
|
作者
Zhu, Heyu [1 ]
Yan, Yuanmei [1 ]
Jiang, Yi [1 ]
Meng, Xianfang [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med Sci, Dept Neurobiol, Wuhan 430030, Peoples R China
基金
中国国家自然科学基金;
关键词
ellagic acid; anti-aging; anti-inflammation; antioxidant; neuroprotection; OXIDATIVE STRESS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; RAT MODEL; INFLAMMATION; ACTIVATION; PATHWAYS; STROKE; CANCER; ALPHA;
D O I
10.3390/ijms231810937
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aging is an unavoidable biological process that leads to the decline of human function and the reduction in people's quality of life. Demand for anti-aging medicines has become very urgent. Many studies have shown that ellagic acid (EA), a phenolic compound widely distributed in dicotyledonous plants, has powerful anti-inflammation and antioxidant properties. Moreover, it has been demonstrated that EA can enhance neuronal viability, reduce neuronal defects, and alleviate damage in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia. This paper reviews the biochemical functions and neuroprotective effects of EA, showing the clinical value of its application.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Anti-aging Effects of Ginseng and Ginsenosides on the Nervous System
    Lai, Min
    Zhang, Hui-juan
    Wang, Fei
    Shao, Ya-lan
    Yang, Mei-wen
    Hong, Fen-fang
    Yang, Shu-long
    [J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2018, 14 (08) : 1188 - 1197
  • [2] Drosophila nervous system as a target of aging and anti-aging interventions
    Omelyanchuk, Leonid V.
    Shaposhnikov, Mikhail V.
    Moskalev, Alexey A.
    [J]. FRONTIERS IN GENETICS, 2015, 6
  • [3] AGING AND ANTI-AGING EFFECTS OF HORMONES
    EVERITT, A
    MEITES, J
    [J]. JOURNALS OF GERONTOLOGY, 1989, 44 (06): : B139 - B147
  • [4] Insights Into Effects of Ellagic Acid on the Nervous System: A Mini Review
    Ahmed, Touqeer
    Setzer, William N.
    Nabavi, Seyed Fazel
    Orhan, Ilkay Erdogan
    Braidy, Nady
    Sobarzo-Sanchez, Eduardo
    Nabavi, Seyed Mohammad
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (10) : 1350 - 1360
  • [5] Metformin - its potential anti-cancer and anti-aging effects
    Podhorecka, Monika
    Ibanez, Blanca
    Dmoszynska, Anna
    [J]. POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2017, 71 : 170 - 175
  • [6] Anti-Aging Effects of Probiotics
    Sharma, Divya
    Kober, Mary-Margaret
    Bowe, Whitney P.
    [J]. JOURNAL OF DRUGS IN DERMATOLOGY, 2016, 15 (01) : 9 - 12
  • [7] Anti-aging effects of coffee
    Takahashi, Keita
    Ishigami, Akihito
    [J]. AGING-US, 2017, 9 (08): : 1863 - 1864
  • [8] HIV and Aging: Effects on the Central Nervous System
    Canizares, Silvia
    Cherner, Mariana
    Ellis, Ronald J.
    [J]. SEMINARS IN NEUROLOGY, 2014, 34 (01) : 27 - 34
  • [9] Anti-Aging of the Nervous System and Related Neurodegenerative Diseases With Chinese Herbal Medicine
    Du, Xiaohui
    Lou, Nanbin
    Hu, Sinan
    Xiao, Ruopeng
    Chu, Chu
    Huang, Qiankai
    Lu, Lin
    Li, Shanshan
    Yang, Jing
    [J]. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2023, 38
  • [10] Clavulanic Acid and its Potential Therapeutic Effects on the Central Nervous System
    Balcazar-Ochoa, Luis Gerardo
    Ventura-Martinez, Rosa
    Angeles-Lopez, Guadalupe Esther
    Gomez-Acevedo, Claudia
    Carrasco, Omar Francisco
    Sampieri-Cabrera, Raul
    Chavarria, Anahi
    Gonzalez-Hernandez, Abimael
    [J]. ARCHIVES OF MEDICAL RESEARCH, 2024, 55 (01)