Oxidation of liposomal membrane suppressed by flavonoids: Quantitative structure-activity relationship

被引：58

作者：

Rackova, L

Firakova, S

Kostalova, D

Stefek, M

Sturdik, E

Majekova, M

机构：

[1] Slovak Acad Sci, Inst Expt Pharmacol, SK-84104 Bratislava, Slovakia

[2] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Dept Biochem Technol, SK-81237 Bratislava, Slovakia

[3] Comenius Univ, Fac Pharm, Dept Pharmacognosy & Bot, SK-83232 Bratislava, Slovakia

[4] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Dept Nutr & Food Assessment, SK-81237 Bratislava, Slovakia

[5] Univ St Cyril & Methudius, Fac Nat Sci, Dept Biotechnol, SK-91700 Trnava, Slovakia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 23期

关键词：

flavonoids; liposomes; antioxidant activity; quantitative structure-activity relationship;

D O I：

10.1016/j.bmc.2005.07.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidant activity of the set of 12 flavonoids in heterogeneous membrane system of dioleoyl phosphatidylcholine liposomes stressed by peroxidative damage induced by 2,2'-azobis-(2-amidinopropane) hydrochloride azoiniciator and evaluated by the thiocyanate method was assessed. Antioxidant activity (pIC(50)) was correlated with 19 molecule parameters calculated for the minimum energy conformers of the compounds tested. The linear regression analysis revealed that the parameter of hydration energy E-HYDR (R = -0.747) was the best predictor of antioxidant activity in a liposomal system. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6477 / 6484

页数：8

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